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A low-molecular-weight protein cross-reacting with human liver N-acetyl-beta-D-glucosaminidase.


ABSTRACT: Antisera were raised to preparations of hexosaminidase isoenzymes A and B purified from human liver. Protein that cross-reacted with the liver hexosaminidase was detected by an antibody-consumption method. A cross-reacting protein with a low molecular weight (20000) was partially characterized and purified from control human liver. This protein is also present in the liver of patients with Tay-Sachs disease or with Sandhoff's disease. Hexosaminidases A and B gave an immunological reaction of partial identity with the low-molecular-weight protein. The possible identity of the low-molecular-weight cross-reacting protein as a subunit of hexosaminidase is discussed.

SUBMITTER: Carroll M 

PROVIDER: S-EPMC1166107 | biostudies-other | 1974 Feb

REPOSITORIES: biostudies-other

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