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Anti-anabolic effects of adenosine 3':5'-cyclic monophosphate. Inhibition of protein synthesis.

ABSTRACT: 1. Evidence is presented that cyclic AMP inhibits the incorporation of l-[4,5-(3)H]leucine into protein in a cell-free system from rat liver. This inhibition occurs after aminoacyl-tRNA formation. 2. Microsomal fractions, isolated after the incubation of postmitochondrial supernatant with cyclic AMP and ATP, show a diminished ability to synthesize protein. Both cyclic AMP and ATP are required for this effect. 3. A possible physiological role for the anti-anabolic action of cyclic AMP is discussed in terms of the control of gluconeogenesis.

SUBMITTER: Sellers A

PROVIDER: S-EPMC1166218 | biostudies-other | 1974 Mar

REPOSITORIES: biostudies-other

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