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Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.


ABSTRACT: S-(+)-3,4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-phosphate, was synthesized stereospecifically and shown to be an effective substrate for rabbit muscle glycerol 3-phosphate dehydrogenase (sn-glycerol 3-phosphate-NAD(+) oxidoreductase, EC 1.1.1.8). Non-isosteric phosphonate analogues of sn-glycerol 3-phosphate showed neither substrate nor inhibitory activity with the enzyme.

SUBMITTER: Adams PR 

PROVIDER: S-EPMC1168179 | biostudies-other | 1974 Sep

REPOSITORIES: biostudies-other

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