The effect of systematic error on the accuracy of Michaelis constants and maximum velocities estimated by using the integrated Michaelis-Menten equation.
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ABSTRACT: Systematic errors in initial substrate concentration (s(0)), product concentration and reaction time give much larger errors in the Michaelis-Menten parameters unless s(0) is treated as an unknown parameter. These errors are difficult to detect because the fitted curve deviates little from the data. The effect of non-enzymic reaction is also examined.
SUBMITTER: Newman PF
PROVIDER: S-EPMC1168449 | biostudies-other | 1974 Dec
REPOSITORIES: biostudies-other
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