TASK, a human background K+ channel to sense external pH variations near physiological pH.
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ABSTRACT:
SUBMITTER: Duprat F
PROVIDER: S-EPMC1170177 | biostudies-other | 1997 Sep
REPOSITORIES: biostudies-other
Publications
TASK, a human background K+ channel to sense external pH variations near physiological pH.
Duprat F F Lesage F F Fink M M Reyes R R Heurteaux C C Lazdunski M M
The EMBO journal 19970901 17
TASK is a new member of the recently recognized TWIK K+ channel family. This 395 amino acid polypeptide has four transmembrane segments and two P domains. In adult human, TASK transcripts are found in pancreas<placenta<brain<lung, prostate<heart, kidney<uterus, small intestine and colon. Electrophysiological properties of TASK were determined after expression in Xenopus oocytes and COS cells. TASK currents are K+-selective, instantaneous and non-inactivating. They show an outward rectification w ...[more]
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