Ontology highlight
ABSTRACT:
SUBMITTER: van Pouderoyen G
PROVIDER: S-EPMC1170234 | biostudies-other | 1997 Oct
REPOSITORIES: biostudies-other
van Pouderoyen G G Ketting R F RF Perrakis A A Plasterk R H RH Sixma T K TK
The EMBO journal 19971001 19
The crystal structure of the complex between the N-terminal DNA-binding domain of Tc3 transposase and an oligomer of transposon DNA has been determined. The specific DNA-binding domain contains three alpha-helices, of which two form a helix-turn-helix (HTH) motif. The recognition of transposon DNA by the transposase is mediated through base-specific contacts and complementarity between protein and sequence-dependent deformations of the DNA. The HTH motif makes four base-specific contacts with th ...[more]