Ontology highlight
ABSTRACT:
SUBMITTER: Butcher SE
PROVIDER: S-EPMC1170348 | biostudies-other | 1997 Dec
REPOSITORIES: biostudies-other
Butcher S E SE Dieckmann T T Feigon J J
The EMBO journal 19971201 24
The GAAA tetraloop receptor is an 11-nucleotide RNA sequence that participates in the tertiary folding of a variety of large catalytic RNAs by providing a specific binding site for GAAA tetraloops. Here we report the solution structure of the isolated tetraloop receptor as solved by multidimensional, heteronuclear magnetic resonance spectroscopy. The internal loop of the tetraloop receptor has three adenosines stacked in a cross-strand or zipper-like fashion. This arrangement produces a high deg ...[more]