Ontology highlight
ABSTRACT:
SUBMITTER: Condorelli G
PROVIDER: S-EPMC1170721 | biostudies-other | 1998 Jul
REPOSITORIES: biostudies-other
Condorelli G G Vigliotta G G Iavarone C C Caruso M M Tocchetti C G CG Andreozzi F F Cafieri A A Tecce M F MF Formisano P P Beguinot L L Beguinot F F
The EMBO journal 19980701 14
We have used differential display to identify genes whose expression is altered in type 2 diabetes thus contributing to its pathogenesis. One mRNA is overexpressed in fibroblasts from type 2 diabetics compared with non-diabetic individuals, as well as in skeletal muscle and adipose tissues, two major sites of insulin resistance in type 2 diabetes. The levels of the protein encoded by this mRNA are also elevated in type 2 diabetic tissues; thus, we named it PED for phosphoprotein enriched in diab ...[more]