Ontology highlight
ABSTRACT:
SUBMITTER: Patel AJ
PROVIDER: S-EPMC1170762 | biostudies-other | 1998 Aug
REPOSITORIES: biostudies-other
Patel A J AJ Honoré E E Maingret F F Lesage F F Fink M M Duprat F F Lazdunski M M
The EMBO journal 19980801 15
Aplysia S-type K+ channels of sensory neurons play a dominant role in presynaptic facilitation and behavioural sensitization. They are closed by serotonin via cAMP-dependent phosphorylation, whereas they are opened by arachidonic acid, volatile general anaesthetics and mechanical stimulation. We have identified a cloned mammalian two P domain K+ channel sharing the properties of the S channel. In addition, the recombinant channel is opened by lipid bilayer amphipathic crenators, while it is clos ...[more]