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A mammalian two pore domain mechano-gated S-like K+ channel.

ABSTRACT: Aplysia S-type K+ channels of sensory neurons play a dominant role in presynaptic facilitation and behavioural sensitization. They are closed by serotonin via cAMP-dependent phosphorylation, whereas they are opened by arachidonic acid, volatile general anaesthetics and mechanical stimulation. We have identified a cloned mammalian two P domain K+ channel sharing the properties of the S channel. In addition, the recombinant channel is opened by lipid bilayer amphipathic crenators, while it is closed by cup-formers. The cytoplasmic C-terminus contains a charged region critical for chemical and mechanical activation, as well as a phosphorylation site required for cAMP inhibition.

SUBMITTER: Patel AJ

PROVIDER: S-EPMC1170762 | biostudies-other | 1998 Aug

REPOSITORIES: biostudies-other

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A mammalian two pore domain mechano-gated S-like K+ channel.

Patel A J AJ Honoré E E Maingret F F Lesage F F Fink M M Duprat F F Lazdunski M M

The EMBO journal 19980801 15

Aplysia S-type K+ channels of sensory neurons play a dominant role in presynaptic facilitation and behavioural sensitization. They are closed by serotonin via cAMP-dependent phosphorylation, whereas they are opened by arachidonic acid, volatile general anaesthetics and mechanical stimulation. We have identified a cloned mammalian two P domain K+ channel sharing the properties of the S channel. In addition, the recombinant channel is opened by lipid bilayer amphipathic crenators, while it is clos ...[more]

PMID: 9687497

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