Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC1170955 | biostudies-other | 1998 Nov
REPOSITORIES: biostudies-other
Li Q Q Herrler M M Landsberger N N Kaludov N N Ogryzko V V VV Nakatani Y Y Wolffe A P AP
The EMBO journal 19981101 21
We identify Xenopus NF-Y as a key regulator of acetylation responsiveness for the Xenopus hsp70 promoter within chromatin assembled in Xenopus oocyte nuclei. Y-box sequences are required for the assembly of DNase I-hypersensitive sites in the hsp70 promoter, and for transcriptional activation both by inhibitors of histone deacetylase and by the p300 acetyltransferase. The viral oncoprotein E1A interferes with both of these activation steps. We clone Xenopus NF-YA, NF-YB and NF-YC and establish t ...[more]