Ontology highlight
ABSTRACT:
SUBMITTER: Cuello P
PROVIDER: S-EPMC1171367 | biostudies-other | 1999 May
REPOSITORIES: biostudies-other
Cuello P P Boyd D C DC Dye M J MJ Proudfoot N J NJ Murphy S S
The EMBO journal 19990501 10
The 3' box of the human class II snRNA genes is required for proper 3' processing of transcripts, but how it functions is unclear. Several lines of evidence suggest that termination of transcription occurs at the 3' box and the terminated transcript is then a substrate for processing. However, using nuclear run-on analysis of endogenous genes, we demonstrate that transcription continues for at least 250 nucleotides beyond the 3' box of the U2 genes. Although in vivo footprinting analysis of both ...[more]