Ontology highlight
ABSTRACT:
SUBMITTER: Casademunt E
PROVIDER: S-EPMC1171670 | biostudies-other | 1999 Nov
REPOSITORIES: biostudies-other
Casademunt E E Carter B D BD Benzel I I Frade J M JM Dechant G G Barde Y A YA
The EMBO journal 19991101 21
NRIF (neurotrophin receptor interacting factor) is a ubiquitously expressed zinc finger protein of the Krüppel family which interacts with the neurotrophin receptor p75(NTR). The interaction was first detected in yeast and then biochemically confirmed using recombinant GST-NRIF fusions and p75(NTR) expressed by eukaryotic cells. Transgenic mice carrying a deletion in the exon encoding the p75(NTR)-binding domain of NRIF display a phenotype which is strongly dependent upon genetic background. Whi ...[more]