Ontology highlight
ABSTRACT:
SUBMITTER: Nichols MD
PROVIDER: S-EPMC1171681 | biostudies-other | 1999 Nov
REPOSITORIES: biostudies-other
Nichols M D MD DeAngelis K K Keck J L JL Berger J M JM
The EMBO journal 19991101 21
In all organisms, type II DNA topoisomerases are essential for untangling chromosomal DNA. We have determined the structure of the DNA-binding core of the Methanococcus jannaschii DNA topoisomerase VI A subunit at 2.0 A resolution. The overall structure of this subunit is unique, demonstrating that archaeal type II enzymes are distinct from other type II topoisomerases. However, the core structure contains a pair of domains that are also found in type IA and classic type II topoisomerases. Toget ...[more]