Unknown

Dataset Information

0

Ascorbic acid, metal ions and the superoxide radical.


ABSTRACT: 1. No evidence could be found for production of the superoxide radical, O2-, during autoxidation of ascorbic acid at alkaline pH values. Indeed, ascorbate may be important in protection against O2- genat-d in vivo. 2. Oxidation of ascorbate at pH 10.2 was stimulated by metal ions. Stimulation by Fe2+ was abolished by superoxide dismutase, probably because of generation of O2-- during reduction of O2 by Fe2+, followed by reaction of O2-- with ascorbate. EDTA changed the mechanism of Fe2+-stimulated ascorbate oxidation. 3. Stimulation of ascorbate oxidation by Cu2+ was also decreased by superoxide dismutase, but this appears to be an artifact, since apoenzyme or bovine serum albumin showed similar effects.

SUBMITTER: Halliwell B 

PROVIDER: S-EPMC1172894 | biostudies-other | 1976 Jun

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1163218 | biostudies-other
| S-EPMC6332015 | biostudies-literature
| S-EPMC5578076 | biostudies-literature
| S-EPMC3622795 | biostudies-literature
| S-EPMC2604981 | biostudies-literature
| S-EPMC7650783 | biostudies-literature
| S-EPMC6661935 | biostudies-literature
| S-EPMC9323265 | biostudies-literature
2010-01-12 | GSE15327 | GEO
| S-EPMC2659422 | biostudies-literature