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The effects of certain glycols, substituted glycols and related organic solvents on the thermal stability of soluble collagen.


ABSTRACT: The effects of a number of related diols, substituted diols and glycerol on the thermal stability of acid-soluble calf skin collagen were investigated. Thermal transition temperatures were determined by optical rotation measurement. Short-chain diols with terminal hydroxyl groups, i.e. ethylene glycol and propane-1,3-diol, stabilized the protein at all accessible concentrations. Stabilization was also observed with glycerol and diethylene glycol. Higher homologues in the diol series produced various effects, as did hydroxyl-group positional isomerism. Monoalkyl substitution of diols progressively lowered the denaturation temperature of collagen. Results are discussed in relation to possible mechanisms of perturbant action.

SUBMITTER: Hart GJ 

PROVIDER: S-EPMC1178097 | biostudies-other | 1971 Nov

REPOSITORIES: biostudies-other

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