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Effect of alpha-amanitin on ribonucleic acid polymerase II of rat brain nuclei and on retention of avoidance conditioning.

ABSTRACT: 1. alpha-Amanitin inhibits in vitro the activity of RNA polymerase II of rat brain nuclei. 2. The toxin does not pass the blood-brain barrier, but when injected intracerebrally is highly toxic for rats, and causes inhibition of RNA polymerase II of isolated brain nuclei. 3. Intracerebral injection of alpha-amanitin 6h before training to a passive avoidance task is followed by impaired performance of rats on retesting after 7 days, without affecting performance on retesting immediately after training.

SUBMITTER: Montanaro N

PROVIDER: S-EPMC1178273 | biostudies-other | 1971 Dec

REPOSITORIES: biostudies-other

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