Unknown

Dataset Information

0

The characterization and stereochemistry of biosynthesis of dolichols in rat liver.


ABSTRACT: It was shown that rat liver contains a series of dolichols with chain lengths of from 17 (or possibly 16) to 21 isoprene residues, the main constituent of the mixture being dolichol-18. By using double-labelled radioactive mevalonates it was demonstrated that each of these dolichols possesses three biogenetically trans-isoprene residues and that the remaining residues are biogenetically cis, suggesting that these polyprenols are biosynthesized from all-trans-farnesyl pyrophosphate by the cis additions of isoprene residues, followed by saturation of the alpha-isoprene residue. The results obtained with these radioactive mevalonates also indicated that the activity of isopentenylpyrophosphate isomerase is low relative to the activity of prenyltransferase in rat liver.

SUBMITTER: Gough DP 

PROVIDER: S-EPMC1179092 | biostudies-other | 1970 Jun

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC1178863 | biostudies-other
| S-EPMC3258935 | biostudies-literature
| S-EPMC3633428 | biostudies-literature
| S-EPMC1198756 | biostudies-other
| S-EPMC1179051 | biostudies-other
| S-EPMC1184938 | biostudies-other
| S-EPMC4768167 | biostudies-literature
| S-EPMC1183844 | biostudies-other
| S-EPMC2890397 | biostudies-literature
| S-EPMC3128684 | biostudies-literature