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Sequence studies on the heavy chain of rabbit immunoglobulin A of different alpha-locus allotypes.

ABSTRACT: The amino acid sequence was determined of part of the variable region of heavy chain from rabbit immunoglobulin A of allotypes a1 and a3. Two corrections of the primary sequence of Aa1 gamma-chains are reported; most of the structural correlates of the alpha-locus allotypes are confirmed. The amino acid sequence of the N-terminal 20 residues of alpha-negative molecules was also determined and found to be homologous to the human VhIII subgroup. These molecules are present in a much higher proportion in the alpha-chain pool than in the gamma-chain.

SUBMITTER: Johnstone AP

PROVIDER: S-EPMC1183643 | biostudies-other | 1977 Oct

REPOSITORIES: biostudies-other

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