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Incorporation of [14C] histidine into homocarnosine and carnosine of frog brain in vivo and in vitro.


ABSTRACT: 1. Homocarnosine, carnosine and histidine were determined in brain from several species and the results compared with values in the literature. 2. [(14)C]Homocarnosine and [(14)C]carnosine were isolated from frog brain after intracerebral injection of [(14)C]histidine in vivo. 3. Whole frog brain, incubated in vitro with l-[(14)C]histidine, formed labelled homocarnosine and carnosine. 4. A frog brain homogenate or supernatant fraction catalysed the incorporation of l-[(14)C]histidine into homocarnosine and carnosine. 5. The results indicate that brain tissue can synthesize homocarnosine and carnosine.

SUBMITTER: Yockey WC 

PROVIDER: S-EPMC1184931 | biostudies-other | 1969 Sep

REPOSITORIES: biostudies-other

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