Regulation of monkey liver serine hydroxymethyltransferase by nicotinamide nucleotide.
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ABSTRACT: The positive homotropic binding of tetrahydrofolate to monkey liver serine hydroxymethyltransferase was abolished on preincubating the enzyme with NADH and NADPH. NAD+ was a negative heterotropic effector, whereas NADP+ was without effect. The allosteric effects of nicotinamide nucleotides on the serine hydroxymethyltransferase, reported for the first time, lead to a better understanding of the regulation of the metabolic interconversion of folate coenzymes.
SUBMITTER: Ramesh KS
PROVIDER: S-EPMC1186011 | biostudies-other | 1978 Sep
REPOSITORIES: biostudies-other
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