6 beta-Bromopenicillanic acid inactivates beta-lactamase I.

ABSTRACT: The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.

SUBMITTER: Knott-Hunziker V 

PROVIDER: S-EPMC1186377 | biostudies-other | 1979 Jan

REPOSITORIES: biostudies-other