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The effects of ovariectomy and injected oestradiol monobenzoate on polypeptide metabolism in the hypothalamus.


ABSTRACT: 1. The activities of two groups of peptidases separated from a homogenate of rabbit hypothalamus were determined (a) in adult female animals, (b) in ovariectomized animals and (c) in intact female animals after injection of oestradiol monobenzoate (15-120mug.). 2. Ovariectomy decreased the enzyme activity initially; the activity in the particulate group of enzymes subsequently returned to normal whereas the activity of the supernatant fraction was less than normal 8 months after operation. 3. Injection of oestradiol monobenzoate increased the enzyme activity in the supernatant fraction to that observed in pregnant animals and in suckled lactating animals. 4. There is a correlation between changes in enzyme activity of the supernatant fraction and conditions that are known to influence gonadotrophin secretion.

SUBMITTER: Hooper KC 

PROVIDER: S-EPMC1187120 | biostudies-other | 1968 Nov

REPOSITORIES: biostudies-other

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