Ontology highlight
ABSTRACT:
SUBMITTER: Nakahara K
PROVIDER: S-EPMC1189302 | biostudies-other | 2005 Aug
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20050812 34
MicroRNAs (miRNAs) are a class of small RNAs that silence gene expression. In animal cells, miRNAs bind to the 3' untranslated regions of specific mRNAs and inhibit their translation. Although some targets of a handful of miRNAs are known, the number and identities of mRNA targets in the genome are uncertain, as are the developmental functions of miRNA regulation. To identify the global range of miRNA-regulated genes during oocyte maturation of Drosophila, we compared the proteome from wild-type ...[more]