Ontology highlight
ABSTRACT:
SUBMITTER: Doumont G
PROVIDER: S-EPMC1201350 | biostudies-other | 2005 Sep
REPOSITORIES: biostudies-other
Doumont Gilles G Martoriati Alain A Beekman Chantal C Bogaerts Sven S Mee Patrick J PJ Bureau Fabrice F Colombo Emanuela E Alcalay Myriam M Bellefroid Eric E Marchesi Francesco F Scanziani Eugenio E Pelicci Pier Giuseppe PG Marine Jean-Christophe JC
The EMBO journal 20050818 17
In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new direct p53 target, Ptprv (or ESP), encoding a transmembrane tyrosine phosphatase. Ptprv transcription is dramatically and preferentially increased in cultured cells undergoing p53-dependent cell cycle arrest, but not in cells undergoing p53-mediated apoptosis. This observation was further confirmed in vi ...[more]