Spectrum of Bmp5 mutations from germline mutagenesis experiments in mice.
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ABSTRACT:
SUBMITTER: Marker PC
PROVIDER: S-EPMC1207807 | biostudies-other | 1997 Feb
REPOSITORIES: biostudies-other
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Spectrum of Bmp5 mutations from germline mutagenesis experiments in mice.
Marker P C PC Seung K K Bland A E AE Russell L B LB Kingsley D M DM
Genetics 19970201 2
Over 40 years of mutagenesis experiments using the mouse specific-locus test have produced a large number of induced germline mutations at seven loci, among them the short ear locus. We have previously shown that the short ear locus encodes bone morphogenetic protein 5 (BMP5), a member of a large family of secreted signaling molecules that play key roles in axis formation, tissue differentiation, mesenchymalepithelial interactions, and skeletal development. Here we examine 24 chemical- and radia ...[more]
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