Unknown

Dataset Information

0

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades.


ABSTRACT: The mitogen-activated protein kinase (MAPK) signalling pathway serves to translocate information from activated plasma-membrane receptors to initiate nuclear transcriptional events. This cascade has recently been subdivided into two analogous pathways: the extracellular signal-regulated kinase (ERK) cascade, which preferentially signals mitogenesis, and the stress-activated protein kinase (SAPK) cascade, which is linked to growth arrest and/or cellular inflammation. In concurrent experiments utilizing rat glomerular mesangial cells (MCs), we demonstrate that growth factors or sphingosine activate ERK but not SAPK. In contrast, inflammatory cytokines or cell-permeable ceramide analogues activate SAPK but not ERK. Ceramide, but not sphingosine, induces interleukin-6 secretion, a marker of an inflamed phenotype. Moreover, ceramide can suppress growth factor- or sphingosine-induced ERK activation as well as proliferation. These studies implicate sphingolipid metabolites as opposing regulators of cell proliferation and inflammation through activation of separate kinase cascades.

SUBMITTER: Coroneos E 

PROVIDER: S-EPMC1217311 | biostudies-other | 1996 May

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC3268412 | biostudies-other
| S-EPMC133695 | biostudies-literature
| S-EPMC3032309 | biostudies-literature
| S-EPMC124141 | biostudies-literature
| S-EPMC2581931 | biostudies-literature
| S-EPMC1222018 | biostudies-other
| S-EPMC2835149 | biostudies-literature
| S-EPMC6725183 | biostudies-literature
| S-EPMC4055629 | biostudies-literature
| S-EPMC3149304 | biostudies-literature