Unknown

Dataset Information

0

Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes.


ABSTRACT: Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.

SUBMITTER: Thomas D 

PROVIDER: S-EPMC1219178 | biostudies-other | 1998 Mar

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC2291453 | biostudies-literature
| S-EPMC3457255 | biostudies-literature
| S-EPMC3542976 | biostudies-literature
| S-EPMC111047 | biostudies-literature
| S-EPMC6792958 | biostudies-literature
| S-EPMC49309 | biostudies-other
| S-EPMC18800 | biostudies-literature
| S-EPMC18888 | biostudies-literature
| S-EPMC3677244 | biostudies-literature
| S-EPMC5469796 | biostudies-literature