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Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.


ABSTRACT: Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

SUBMITTER: Milton NG 

PROVIDER: S-EPMC1220643 | biostudies-other | 1999 Dec

REPOSITORIES: biostudies-other

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