Unknown

Dataset Information

0

Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.


ABSTRACT: Amyloid-beta (Abeta) specifically bound purified catalase with high affinity and inhibited catalase breakdown of H(2)O(2). The Abeta-induced catalase inhibition involved formation of the inactive catalase Compound II and was reversible. Catalase<-->Abeta interactions provide rapid functional assays for the cytotoxic domain of Abeta and suggest a mechanism for some of the observed actions of Abeta plus catalase in vitro.

SUBMITTER: Milton NG 

PROVIDER: S-EPMC1220643 | biostudies-other | 1999 Dec

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC2863026 | biostudies-literature
| S-EPMC122654 | biostudies-literature
2005-01-01 | E-MEXP-710 | biostudies-arrayexpress
| S-EPMC91612 | biostudies-literature
| S-EPMC9794787 | biostudies-literature
| S-EPMC4134286 | biostudies-literature
| S-EPMC4315425 | biostudies-literature
| S-EPMC2431018 | biostudies-literature
| S-EPMC1187433 | biostudies-other
| S-EPMC9411925 | biostudies-literature