Unknown

Dataset Information

0

Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.


ABSTRACT: Receptor-activity-modifying proteins (RAMPs) with single transmembrane domains define the function of two G-protein-coupled receptors of the B family. Cell-surface complexes of human RAMP1 (hRAMP1) and human calcitonin (CT) receptor isotype 2 (hCTR2) or rat CT-receptor-like receptor (rCRLR) have now been identified through protein cross-linking, co-immunoprecipitation and confocal microscopy. They are two distinct CT-gene-related peptide (CGRP) receptors coupled to cAMP production and pharmacologically distinguished by the CT and CGRP antagonists salmon CT(8-32) and human or rat CGRP(8-37). Thus direct molecular interactions of hRAMP1 with hCTR2 or rCRLR are required for CGRP recognition. hCTR2, moreover, adopts non-traditional functions through its association with hRAMP1.

SUBMITTER: Leuthauser K 

PROVIDER: S-EPMC1221370 | biostudies-other | 2000 Oct

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4360564 | biostudies-literature
| S-EPMC1679777 | biostudies-other
| S-EPMC2937196 | biostudies-literature
| S-EPMC5521955 | biostudies-literature
| S-EPMC9832379 | biostudies-literature
| S-EPMC6115637 | biostudies-literature
| S-EPMC5435731 | biostudies-literature
| S-EPMC9847135 | biostudies-literature
| S-EPMC5474883 | biostudies-literature
| S-EPMC4504005 | biostudies-literature