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Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.


ABSTRACT: The mechanisms leading to the ubiquitination and degradation of the activated c-Abl kinase have not yet been identified. We found that the multi-adaptor protein ArgBP2 links c-Abl to the ubiquitin ligase Cbl. Phosphorylation of Cbl and ArgBP2 by c-Abl resulted in the stabilization of their interactions, thus facilitating Cbl-induced ubiquitination and subsequent degradation of c-Abl and ArgBP2.

SUBMITTER: Soubeyran P 

PROVIDER: S-EPMC1223168 | biostudies-other | 2003 Feb

REPOSITORIES: biostudies-other

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