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Protein conformation: through a lens, darkly.


ABSTRACT: This commentary describes the study by Calleja and co-workers, who have used fluorescence resonance energy transfer between two fluorescent proteins fused to one protein kinase (protein kinase B/Akt) to reveal conformational changes in a functional protein. The findings of their study offer an intriguing insight into the behaviour of an enzyme that is essential for multiple aspects of mammalian signalling.

SUBMITTER: Insall R 

PROVIDER: S-EPMC1223390 | biostudies-other | 2003 May

REPOSITORIES: biostudies-other

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