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Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition.


ABSTRACT: The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.

SUBMITTER: Gogvadze V 

PROVIDER: S-EPMC1223940 | biostudies-other | 2004 Feb

REPOSITORIES: biostudies-other

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