Ontology highlight
ABSTRACT:
SUBMITTER: Khaidakov M
PROVIDER: S-EPMC1232865 | biostudies-other | 2005
REPOSITORIES: biostudies-other
Khaidakov M M Shmookler Reis R J RJ
Molecular cancer 20050913
Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutati ...[more]