Explicit equilibrium modeling of transcription-factor binding and gene regulation.
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ABSTRACT:
SUBMITTER: Granek JA
PROVIDER: S-EPMC1257470 | biostudies-other | 2005
REPOSITORIES: biostudies-other
Publications
Explicit equilibrium modeling of transcription-factor binding and gene regulation.
Granek Joshua A JA Clarke Neil D ND
Genome biology 20050930 10
We have developed a computational model that predicts the probability of transcription factor binding to any site in the genome. GOMER (generalizable occupancy model of expression regulation) calculates binding probabilities on the basis of position weight matrices, and incorporates the effects of cooperativity and competition by explicit calculation of coupled binding equilibria. GOMER can be used to test hypotheses regarding gene regulation that build upon this physically principled prediction ...[more]
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