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The fate of acetyl groups derived from glucose in the isolated perfused goat udder.


ABSTRACT: 1. In the isolated perfused goat mammary gland, both glucose and acetate contribute 20-30% of carbon to citrate via acetyl-CoA. 2. Carbon dioxide does not contribute significantly to the formation of acetyl-CoA. 3. ATP citrate lyase, which, in rats, yields acetyl-CoA for fatty acid synthesis, is absent from or very low in high-speed supernatant fraction of ruminant tissue. 4. It is reasonable to infer that intramitochondrial acetyl-CoA, to which both glucose and acetate contribute, is separated from extramitochondrial acetyl-CoA to which glucose does not contribute and which is used for fatty acid synthesis.

SUBMITTER: Hardwick DC 

PROVIDER: S-EPMC1264979 | biostudies-other | 1966 Apr

REPOSITORIES: biostudies-other

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2022-01-31 | GSE127429 | GEO