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C20 steroids. The metabolism of 3-hydroxy-19-nor[21-14C]pregna-1,3,5(10)-trien-20-one in the rabbit.

ABSTRACT: 1. The metabolism of 3-hydroxy-19-norpregna-1,3,5(10)-trien-20-one, a possible product of the aromatization of progesterone or pregnenolone, has been studied. 2. After oral administration of this C(20) steroid as the 21-(14)C-labelled compound to two groups of rabbits, the excretion pattern of metabolites in the urine was examined. 3. At 14 days after administration, 3.3-6.5% of the radioactivity had appeared in the urine, 71-79% in the faeces and approx. 10% remained in the gut. 4. A metabolite, isolated from urine mainly as the unconjugated steroid, was identified as 19-norpregna-1,3,5(10)-triene-3,20alpha-diol and constituted 18.5-22% of the total urinary radioactivity. 5. A minor component of the urinary unconjugated steroids was identified as 19-norpregna-1,3,5(10)-triene-3,17alpha,20alpha-triol. 6. A further 2-7.5% of the total urinary radioactivity, isolated only from the urinary sulphate fraction, was tentatively identified as an 18-oxygenated derivative of the administered steroid.

SUBMITTER: Schulster D

PROVIDER: S-EPMC1270480 | biostudies-other | 1967 Jun

REPOSITORIES: biostudies-other

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Crystal structure of 16-ferrocenylmethyl-3?-hydroxy-estra-1,3,5(10)-trien-17-one: a potential chemotherapeutic drug.

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| S-EPMC2969661 | biostudies-literature

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Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency.

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Total Syntheses of 11-Acetoxy-4-deoxyasbestinin?D, 4-Deoxyasbestinin?C, Asbestinin-10, -20, -21 and -23.

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Synthesis and evaluation of 17?-E-20-(heteroaryl)norpregn-1,3,5(10),20 tetraene-3,17?-diols [17?-(heteroaryl)vinyl estradiols] as ligands for the estrogen receptor-? ligand binding domain (ER?-LBD).

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| S-EPMC3259610 | biostudies-literature

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