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Effect of administration of the carcinogen dimethylnitrosamine on urinary 7-methylguanine.


ABSTRACT: 1. Evidence is presented for the excretion of 7-methylguanine in normal rat urine at a rate of approx. 65mug./day. Experiments with animals in which the nucleic acids had been prelabelled by treatment of the neonatal rats with [(14)C]-formate gave evidence that the methylated base originated in the nucleic acids of the rat. 2. Injection of [(14)C]dimethylnitrosamine leads to an increased excretion of 7-methylguanine, and the base becomes labelled in the methyl group. The disappearance of labelled 7-methylguanine formed in nucleic acids of rats treated with the carcinogen therefore does not take place by an N-demethylation reaction, but by liberation of the intact methylated base.

SUBMITTER: Craddock VM 

PROVIDER: S-EPMC1270604 | biostudies-other | 1967 Aug

REPOSITORIES: biostudies-other

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