Ontology highlight
ABSTRACT:
SUBMITTER: Anthony RG
PROVIDER: S-EPMC1271803 | biostudies-other | 2004 Feb
REPOSITORIES: biostudies-other
Anthony Richard G RG Henriques Rossana R Helfer Anne A Mészáros Tamás T Rios Gabino G Testerink Christa C Munnik Teun T Deák Maria M Koncz Csaba C Bögre László L
The EMBO journal 20040129 3
Here we report on a lipid-signalling pathway in plants that is downstream of phosphatidic acid and involves the Arabidopsis protein kinase, AGC2-1, regulated by the 3'-phosphoinositide-dependent kinase-1 (AtPDK1). AGC2-1 specifically interacts with AtPDK1 through a conserved C-terminal hydrophobic motif that leads to its phosphorylation and activation, whereas inhibition of AtPDK1 expression by RNA interference abolishes AGC2-1 activity. Phosphatidic acid specifically binds to AtPDK1 and stimula ...[more]