Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.
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ABSTRACT:
SUBMITTER: Laval SH
PROVIDER: S-EPMC1275646 | biostudies-other | 2001 Apr
REPOSITORIES: biostudies-other
Publications
Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci.
Laval S H SH Timms A A Edwards S S Bradbury L L Brophy S S Milicic A A Rubin L L Siminovitch K A KA Weeks D E DE Calin A A Wordsworth B P BP Brown M A MA
American journal of human genetics 20010227 4
Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point and multipoint nonparametric linkage analysis was performed. Regions were identified showing "suggestive" or stronger linkage with the disease on chromosomes 1p, 2q, 6p, 9q, 10q, 16q, and 19q. The MHC ...[more]
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