Ontology highlight
ABSTRACT:
SUBMITTER: Ino A
PROVIDER: S-EPMC1277836 | biostudies-other | 2005 Oct
REPOSITORIES: biostudies-other
Ino Asami A Naito Yasuhiro Y Mizuguchi Hiroyuki H Handa Naofumi N Hayakawa Takao T Kobayashi Ichizo I
Genetic vaccines and therapy 20051012
<h4>Background</h4>Gene targeting in vivo provides a potentially powerful method for gene analysis and gene therapy. In order to sensitively detect and accurately measure designed sequence changes, we have used a transgenic mouse system, MutaMouse, which has been developed for detection of mutation in vivo. It carries bacteriophage lambda genome with lacZ+ gene, whose change to lacZ-negative allele is detected after in vitro packaging into bacteriophage particles. We have also demonstrated that ...[more]