Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC1298846 | biostudies-other | 2005 Dec
REPOSITORIES: biostudies-other
Kumar Ambuj A Soares Heloisa H Wells Robert R Clarke Mike M Hozo Iztok I Bleyer Archie A Reaman Gregory G Chalmers Iain I Djulbegovic Benjamin B
BMJ (Clinical research ed.) 20051118 7528
<h4>Objectives</h4>To assess how often new treatments for childhood cancer assessed in phase III randomised trials are superior or inferior to standard treatments and whether the pattern of successes and failures in new treatments is consistent with uncertainty being the ethical basis for enrolling patients in such trials.<h4>Design</h4>Observational study.<h4>Setting</h4>Phase III randomised controlled trials carried out under the aegis of the Children's Oncology Group between 1955 and 1997, re ...[more]