Convergent evolution of gene networks by single-gene duplications in higher eukaryotes.
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ABSTRACT:
SUBMITTER: Amoutzias GD
PROVIDER: S-EPMC1299007 | biostudies-other | 2004 Mar
REPOSITORIES: biostudies-other
Publications
Convergent evolution of gene networks by single-gene duplications in higher eukaryotes.
Amoutzias Gregory D GD Robertson David L DL Oliver Stephen G SG Bornberg-Bauer Erich E
EMBO reports 20040213 3
By combining phylogenetic, proteomic and structural information, we have elucidated the evolutionary driving forces for the gene-regulatory interaction networks of basic helix-loop-helix transcription factors. We infer that recurrent events of single-gene duplication and domain rearrangement repeatedly gave rise to distinct networks with almost identical hub-based topologies, and multiple activators and repressors. We thus provide the first empirical evidence for scale-free protein networks emer ...[more]
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