Ontology highlight
ABSTRACT:
SUBMITTER: Zhou G
PROVIDER: S-EPMC1300751 | biostudies-other | 2000 Mar
REPOSITORIES: biostudies-other
Zhou G G Ellington W R WR Chapman M S MS
Biophysical journal 20000301 3
Creatine kinase (CK) and arginine kinase (AK) are related enzymes that reversibly transfer a phosphoryl group between a guanidino compound and ADP. In the buffering of ATP energy levels, they are central to energy metabolism and have been paradigms of classical enzymology. Comparison of the open substrate-free structure of CK and the closed substrate-bound structure of AK reveals differences that are consistent with prior biophysical evidence of substrate-induced conformational changes. Large an ...[more]