A self-consistent knowledge-based approach to protein design.
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ABSTRACT:
SUBMITTER: Rossi A
PROVIDER: S-EPMC1301249 | biostudies-other | 2001 Jan
REPOSITORIES: biostudies-other
Publications
A self-consistent knowledge-based approach to protein design.
Rossi A A Micheletti C C Seno F F Maritan A A
Biophysical journal 20010101 1
A simple and very efficient protein design strategy is proposed by developing some recently introduced theoretical tools which have been successfully applied to exactly solvable protein models. The design approach is implemented by using three amino acid classes and it is based on the minimization of an appropriate energy function. For a given native state the results of the design procedure are compared, through a statistical analysis, with the properties of an ensemble of sequences folding in ...[more]
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