Ontology highlight
ABSTRACT:
SUBMITTER: Zhou HX
PROVIDER: S-EPMC1302391 | biostudies-other | 2002 Dec
REPOSITORIES: biostudies-other
Biophysical journal 20021201 6
The enrichment of salt bridges and hydrogen bonding in thermophilic proteins has long been recognized. Another tendency, featuring lower heat capacity of unfolding (DeltaC(p)) than found in mesophilic proteins, is emerging from the recent literature. Here we present a simple electrostatic model to illustrate that formation of a salt-bridge or hydrogen-bonding network around an ionized group in the folded state leads to increased folding stability and decreased DeltaC(p). We thus suggest that the ...[more]