Direct molecular dynamics observation of protein folding transition state ensemble.
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ABSTRACT:
SUBMITTER: Ding F
PROVIDER: S-EPMC1302427 | biostudies-other | 2002 Dec
REPOSITORIES: biostudies-other
Publications
Direct molecular dynamics observation of protein folding transition state ensemble.
Ding Feng F Dokholyan Nikolay V NV Buldyrev Sergey V SV Stanley H Eugene HE Shakhnovich Eugene I EI
Biophysical journal 20021201 6
The concept of the protein transition state ensemble (TSE), a collection of the conformations that have 50% probability to convert rapidly to the folded state and 50% chance to rapidly unfold, constitutes the basis of the modern interpretation of protein engineering experiments. It has been conjectured that conformations constituting the TSE in many proteins are the expanded and distorted forms of the native state built around a specific folding nucleus. This view has been supported by a number ...[more]
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