Ontology highlight
ABSTRACT:
SUBMITTER: Kim JY
PROVIDER: S-EPMC1308885 | biostudies-other | 2005 Dec
REPOSITORIES: biostudies-other
Kim Jung Yeon JY Tavaré Simon S Shibata Darryl D
Proceedings of the National Academy of Sciences of the United States of America 20051128 49
Cell proliferation may be altered in many diseases, but it is uncertain exactly how to measure total numbers of divisions. Although it is impossible to count every division directly, potentially total numbers of stem cell divisions since birth may be inferred from numbers of somatic errors. The idea is that divisions are surreptitiously recorded by random errors that occur during replication. To test this "molecular clock" hypothesis, epigenetic errors encoded in certain methylation patterns wer ...[more]