Ontology highlight
ABSTRACT:
SUBMITTER: Sakata E
PROVIDER: S-EPMC1315892 | biostudies-other | 2003 Mar
REPOSITORIES: biostudies-other
Sakata Eri E Yamaguchi Yoshiki Y Kurimoto Eiji E Kikuchi Jun J Yokoyama Shigeyuki S Yamada Shingo S Kawahara Hiroyuki H Yokosawa Hideyoshi H Hattori Nobutaka N Mizuno Yoshikuni Y Tanaka Keiji K Kato Koichi K
EMBO reports 20030301 3
Parkin, a product of the causative gene of autosomal-recessive juvenile parkinsonism (AR-JP), is a RING-type E3 ubiquitin ligase and has an amino-terminal ubiquitin-like (Ubl) domain. Although a single mutation that causes an Arg to Pro substitution at position 42 of the Ubl domain (the Arg 42 mutation) has been identified in AR-JP patients, the function of this domain is not clear. In this study, we determined the three-dimensional structure of the Ubl domain of parkin by NMR, in particular by ...[more]