Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC1326157 | biostudies-other | 2006 Jan
REPOSITORIES: biostudies-other
Chen Bo B Mariano Jennifer J Tsai Yien Che YC Chan Anna H AH Cohen Mickael M Weissman Allan M AM
Proceedings of the National Academy of Sciences of the United States of America 20060103 2
Efficient targeting of proteins for degradation from the secretory pathway is essential to homeostasis. This occurs through endoplasmic reticulum (ER)-associated degradation (ERAD). In this study, we establish that a human ubiquitin ligase (E3), gp78, and a specific E2, Ube2g2, are both critically important for ERAD of multiple substrates. gp78 exhibits a complex domain structure that, in addition to the RING finger, includes a ubiquitin-binding Cue domain and a specific binding site for Ube2g2. ...[more]