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LOCATE: a mouse protein subcellular localization database.

ABSTRACT: We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunofluorescence-based assay and by manually reviewing >1700 peer-reviewed publications. LOCATE represents the first effort to catalogue the experimentally verified subcellular location and membrane organization of mammalian proteins using a high-throughput approach and provides localization data for approximately 40% of the mouse proteome. It is available at http://locate.imb.uq.edu.au.

SUBMITTER: Fink JL

PROVIDER: S-EPMC1347432 | biostudies-other | 2006 Jan

REPOSITORIES: biostudies-other

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LOCATE: a mouse protein subcellular localization database.

Fink J Lynn JL Aturaliya Rajith N RN Davis Melissa J MJ Zhang Fasheng F Hanson Kelly K Teasdale Melvena S MS Kai Chikatoshi C Kawai Jun J Carninci Piero P Hayashizaki Yoshihide Y Teasdale Rohan D RD

Nucleic acids research 20060101 Database issue

We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunofluorescence-based assay and by manually reviewing >1700 peer-reviewed publications. LOCATE represents the ...[more]

PMID: 16381849

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